Linked Life Data

12363402

Source:http://linkedlifedata.com/resource/pubmed/id/12363402

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-10-4
pubmed:abstractText
Modulation of short-term plasticity by activation of group III metabotropic glutamate receptors (mGluR) was investigated in the lateral perforant path of the dentate gyrus of the rat hippocampus in vitro. Brief trains of stimulation (10 stimuli at 1-100 Hz) evoked short-term depression of field excitatory postsynaptic potentials (EPSPs), with a steady-state level of short-term depression being attained after approximately 5 stimuli. The steady-state level of depression was frequency-dependent, increasing linearly between 1 and 200 Hz. The curve relating transmitter release per unit time to frequency of stimulation increased linearly up to a limiting frequency of 20-50 Hz, and then flattened at higher frequencies. Activation of group III mGluR by the selective agonist L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) had two distinct actions. Firstly, the test EPSP evoked at low test frequencies was inhibited, and secondly, short-term depression evoked at high frequencies was reduced in a frequency and agonist concentration-dependent manner. Short-term facilitation became prominent at high stimulation frequencies as short-term depression was inhibited by activation of group III mGluR. Activation of group III mGluR also shifted the limiting frequency to higher values.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
952
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Presynaptic group III mGluR modulation of short-term plasticity in the lateral perforant path of the dentate gyrus in vitro.
pubmed:affiliation
Department of Physiology, Trinity College, Dublin 2, Ireland.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't