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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2002-10-3
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pubmed:abstractText |
An important issue in Metazoan development is to understand the mechanisms that lead to stereotyped patterns of programmed cell death. In particular, cells programmed to die may arise from asymmetric cell divisions. The mechanisms underlying such binary cell death decisions are unknown. We describe here a Drosophila sensory organ lineage that generates a single multidentritic neuron in the embryo. This lineage involves two asymmetric divisions. Following each division, one of the two daughter cells expresses the pro-apoptotic genes reaper and grim and subsequently dies. The protein Numb appears to be specifically inherited by the daughter cell that does not die. Numb is necessary and sufficient to prevent apoptosis in this lineage. Conversely, activated Notch is sufficient to trigger death in this lineage. These results show that binary cell death decision can be regulated by the unequal segregation of Numb at mitosis. Our study also indicates that regulation of programmed cell death modulates the final pattern of sensory organs in a segment-specific manner.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cut protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Juvenile Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/grim protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/numb protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/reaper protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4677-84
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pubmed:dateRevised |
2008-10-15
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pubmed:meshHeading |
pubmed-meshheading:12361960-Animals,
pubmed-meshheading:12361960-Apoptosis,
pubmed-meshheading:12361960-Cell Death,
pubmed-meshheading:12361960-Cell Division,
pubmed-meshheading:12361960-Cell Lineage,
pubmed-meshheading:12361960-Drosophila Proteins,
pubmed-meshheading:12361960-Drosophila melanogaster,
pubmed-meshheading:12361960-Embryo, Nonmammalian,
pubmed-meshheading:12361960-Homeodomain Proteins,
pubmed-meshheading:12361960-Juvenile Hormones,
pubmed-meshheading:12361960-Membrane Proteins,
pubmed-meshheading:12361960-Mitosis,
pubmed-meshheading:12361960-Nerve Tissue Proteins,
pubmed-meshheading:12361960-Neurons, Afferent,
pubmed-meshheading:12361960-Neuropeptides,
pubmed-meshheading:12361960-Nuclear Proteins,
pubmed-meshheading:12361960-Receptors, Notch,
pubmed-meshheading:12361960-Sense Organs,
pubmed-meshheading:12361960-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Binary cell death decision regulated by unequal partitioning of Numb at mitosis.
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pubmed:affiliation |
Ecole Normale Supérieure, CNRS UMR 8542, 46 rue d'Ulm, 75230 Paris Cedex 05, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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