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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-10-2
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pubmed:abstractText |
Giardiasis causes malabsorptive diarrhea, and symptoms can be present in the absence of any significant morphologic injury to the intestinal mucosa. The effects of giardiasis on epithelial permeability in vivo remain unknown, and the role of T cells and myosin light chain kinase (MLCK) in altered intestinal barrier function is unclear. This study was conducted to determine whether Giardia spp. alters intestinal permeability in vivo, to assess whether these abnormalities are dependent on T cells, and to assess the role of MLCK in altered epithelial barrier function.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1179-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12360480-Actins,
pubmed-meshheading:12360480-Animals,
pubmed-meshheading:12360480-Cells, Cultured,
pubmed-meshheading:12360480-Female,
pubmed-meshheading:12360480-Giardia lamblia,
pubmed-meshheading:12360480-Giardiasis,
pubmed-meshheading:12360480-Humans,
pubmed-meshheading:12360480-Intestinal Absorption,
pubmed-meshheading:12360480-Intestinal Mucosa,
pubmed-meshheading:12360480-Intestine, Small,
pubmed-meshheading:12360480-Membrane Proteins,
pubmed-meshheading:12360480-Mice,
pubmed-meshheading:12360480-Mice, Inbred Strains,
pubmed-meshheading:12360480-Mice, Nude,
pubmed-meshheading:12360480-Myosin-Light-Chain Kinase,
pubmed-meshheading:12360480-Phosphoproteins,
pubmed-meshheading:12360480-Phosphorylation,
pubmed-meshheading:12360480-Specific Pathogen-Free Organisms,
pubmed-meshheading:12360480-T-Lymphocytes
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pubmed:year |
2002
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pubmed:articleTitle |
Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion.
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pubmed:affiliation |
Department of Biological Sciences, University of Calgary, Alberta, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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