Source:http://linkedlifedata.com/resource/pubmed/id/12359433
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-10-2
|
| pubmed:databankReference | |
| pubmed:abstractText |
A novel papillomavirus was cloned from hyperkeratotic cutaneous lesions of a Persian domestic cat. The Felis domesticus papillomavirus (FdPV-1) genome counts 8300 bp and has a typical genome structure with an early region (E1, E2, E4, E6, E7), a late region (L1, L2), and a noncoding upstream regulatory region (URR or NCR1) between the end of L1 and the beginning of E6. The FdPV-1 also shows an unusual second noncoding region (NCR2) of 1.3 kb, situated between the end of E2 and the beginning of L2. This NCR2 is uniquely related to a similar region in the canine oral papillomavirus (COPV). Phylogenetic analysis places FdPV-1 together with COPV, the cottontail rabbit papillomavirus, human papillomavirus type 1 (HPV-1), and HPV-63 in the group of the benign cutaneous papillomaviruses. The position of FdPV-1 in the phylogenetic tree allows us to hypothesize that already in an early phase of the papillomavirus molecular evolution, a split occurred into viruses with a dual tropism primarily for cutaneous epithelia but also secondarily for mucosal surfaces, and viruses with a specific monotropism for mucosal surfaces. The close relationship between FdPV-1 and COPV, and between their Canidae and Felidae hosts, supports the hypothesis that papillomaviruses have speciated and coevolved together with their hosts throughout vertebrate evolution. A papillomavirus mutation rate of 0.73 to 0.96 x 10(-8) nucleotide substitutions per base per year was calculated.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
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| pubmed:issn |
0042-6822
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
301
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
313-21
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:12359433-Animals,
pubmed-meshheading:12359433-Base Sequence,
pubmed-meshheading:12359433-Biological Evolution,
pubmed-meshheading:12359433-Cat Diseases,
pubmed-meshheading:12359433-Cats,
pubmed-meshheading:12359433-Cloning, Molecular,
pubmed-meshheading:12359433-DNA, Viral,
pubmed-meshheading:12359433-Genes, Viral,
pubmed-meshheading:12359433-Genome, Viral,
pubmed-meshheading:12359433-Humans,
pubmed-meshheading:12359433-Molecular Sequence Data,
pubmed-meshheading:12359433-Open Reading Frames,
pubmed-meshheading:12359433-Papillomaviridae,
pubmed-meshheading:12359433-Papillomavirus Infections,
pubmed-meshheading:12359433-Phylogeny,
pubmed-meshheading:12359433-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:12359433-Sequence Homology, Nucleic Acid,
pubmed-meshheading:12359433-Tumor Virus Infections
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Cloning and genomic characterization of Felis domesticus papillomavirus type 1.
|
| pubmed:affiliation |
Department of Experimental Virology, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|