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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-10-2
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pubmed:abstractText |
In B-cell chronic lymphocytic leukemia (CLL) a high Bcl-2/Bax ratio contributes to death defiance. We sought to identify any genetic changes in the BAX as a possible mechanism for its altered expression in CLL. The BAX gene from the RL cell line and B-cells from 34 CLL patients and 25 controls were sequenced. A novel heterozygous G(-248)A polymorphism in the 5'-UTR was present in 69% of stage I-IV patients and 5.5% of stage 0 patients, and in 4.0% of controls. It was associated with reduced protein expression (P=0.049), progression beyond Rai stage 0 (P=0.00018) and failure to achieve complete response (P=0.038).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-205
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12359369-5' Untranslated Regions,
pubmed-meshheading:12359369-Aged,
pubmed-meshheading:12359369-Aged, 80 and over,
pubmed-meshheading:12359369-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:12359369-Base Sequence,
pubmed-meshheading:12359369-Blotting, Western,
pubmed-meshheading:12359369-Case-Control Studies,
pubmed-meshheading:12359369-Cyclophosphamide,
pubmed-meshheading:12359369-Disease Progression,
pubmed-meshheading:12359369-Doxorubicin,
pubmed-meshheading:12359369-Drug Resistance, Neoplasm,
pubmed-meshheading:12359369-Female,
pubmed-meshheading:12359369-Humans,
pubmed-meshheading:12359369-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:12359369-Male,
pubmed-meshheading:12359369-Middle Aged,
pubmed-meshheading:12359369-Molecular Sequence Data,
pubmed-meshheading:12359369-Polymorphism, Single Nucleotide,
pubmed-meshheading:12359369-Prednisone,
pubmed-meshheading:12359369-Promoter Regions, Genetic,
pubmed-meshheading:12359369-Proto-Oncogene Proteins,
pubmed-meshheading:12359369-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12359369-Treatment Outcome,
pubmed-meshheading:12359369-Vincristine,
pubmed-meshheading:12359369-bcl-2-Associated X Protein
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pubmed:year |
2002
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pubmed:articleTitle |
Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance.
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pubmed:affiliation |
Department of Pathology, Royal University Hospital and College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. saxena@sask.usask.ca
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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