Linked Life Data

12359349

Source:http://linkedlifedata.com/resource/pubmed/id/12359349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2002-10-2
pubmed:abstractText
Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
187
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12359349-Animals, pubmed-meshheading:12359349-Antibiotics, Antineoplastic, pubmed-meshheading:12359349-Bleomycin, pubmed-meshheading:12359349-Carcinogens, pubmed-meshheading:12359349-DNA, pubmed-meshheading:12359349-DNA Damage, pubmed-meshheading:12359349-Deoxyguanosine, pubmed-meshheading:12359349-Ferric Compounds, pubmed-meshheading:12359349-Kidney, pubmed-meshheading:12359349-Lac Operon, pubmed-meshheading:12359349-Liver, pubmed-meshheading:12359349-Lung, pubmed-meshheading:12359349-Male, pubmed-meshheading:12359349-Mice, pubmed-meshheading:12359349-Mice, Inbred BALB C, pubmed-meshheading:12359349-Mice, Inbred DBA, pubmed-meshheading:12359349-Mutagenesis, pubmed-meshheading:12359349-Nitrilotriacetic Acid, pubmed-meshheading:12359349-Oxidation-Reduction, pubmed-meshheading:12359349-Oxidative Stress, pubmed-meshheading:12359349-Oxygen, pubmed-meshheading:12359349-Reactive Oxygen Species
pubmed:year
2002
pubmed:articleTitle
Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice.
pubmed:affiliation
Department of Basic Sciences, New York University, Dental Center, 345 East 24th Street, New York, NY 10100, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.