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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0022180,
umls-concept:C0037791,
umls-concept:C0332120,
umls-concept:C0332311,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0521116,
umls-concept:C1280500,
umls-concept:C1711351,
umls-concept:C2333134
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pubmed:issue |
4
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pubmed:dateCreated |
2002-10-1
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pubmed:abstractText |
Developmental changes in NR1 splice variants and NR2 subunits of the N-methyl-D-aspartate (NMDA) receptor have been associated with changes in the sensitivity of NMDA receptors to agonists, antagonists, and pharmacologic modulators. The authors have investigated changes in the effect of isoflurane on NMDA-gated currents from cultured cortical neurons with time in culture and related these changes to the subunit composition of the NMDA receptors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
856-67
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12357151-Anesthetics, Inhalation,
pubmed-meshheading:12357151-Animals,
pubmed-meshheading:12357151-Cells, Cultured,
pubmed-meshheading:12357151-Cerebral Cortex,
pubmed-meshheading:12357151-Excitatory Amino Acid Antagonists,
pubmed-meshheading:12357151-Ion Channel Gating,
pubmed-meshheading:12357151-Isoflurane,
pubmed-meshheading:12357151-Neurons,
pubmed-meshheading:12357151-Patch-Clamp Techniques,
pubmed-meshheading:12357151-Piperidines,
pubmed-meshheading:12357151-Rats,
pubmed-meshheading:12357151-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:12357151-Recombinant Proteins,
pubmed-meshheading:12357151-Tachyphylaxis,
pubmed-meshheading:12357151-Time Factors,
pubmed-meshheading:12357151-Transfection
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pubmed:year |
2002
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pubmed:articleTitle |
Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity.
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pubmed:affiliation |
Anesthesiology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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