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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-10-1
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pubmed:abstractText |
Cardiac surgery involving cardiopulmonary bypass (CPB) leads to fulminant activation of the hemostatic-inflammatory system. The authors hypothesized that heparin concentration-based anticoagulation management compared with activated clotting time-based heparin management during CPB leads to more effective attenuation of hemostatic activation and inflammatory response. In a randomized prospective study, the authors compared the influence of anticoagulation with a heparin concentration-based system (Hepcon HMS; Medtronic, Minneapolis, MN) to that of activated clotting time-based management on the activation of the hemostatic-inflammatory system during CPB.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
837-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12357148-Adult,
pubmed-meshheading:12357148-Aged,
pubmed-meshheading:12357148-Aged, 80 and over,
pubmed-meshheading:12357148-Anesthesia,
pubmed-meshheading:12357148-Anticoagulants,
pubmed-meshheading:12357148-Biological Markers,
pubmed-meshheading:12357148-Blood Cell Count,
pubmed-meshheading:12357148-Blood Loss, Surgical,
pubmed-meshheading:12357148-Blood Transfusion,
pubmed-meshheading:12357148-Cardiac Surgical Procedures,
pubmed-meshheading:12357148-Cardiopulmonary Bypass,
pubmed-meshheading:12357148-Female,
pubmed-meshheading:12357148-Hemostasis,
pubmed-meshheading:12357148-Heparin,
pubmed-meshheading:12357148-Humans,
pubmed-meshheading:12357148-Inflammation,
pubmed-meshheading:12357148-Male,
pubmed-meshheading:12357148-Middle Aged,
pubmed-meshheading:12357148-Platelet Count,
pubmed-meshheading:12357148-Prospective Studies,
pubmed-meshheading:12357148-Treatment Outcome,
pubmed-meshheading:12357148-Whole Blood Coagulation Time
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pubmed:year |
2002
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pubmed:articleTitle |
Hemostatic activation and inflammatory response during cardiopulmonary bypass: impact of heparin management.
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pubmed:affiliation |
Department of Anesthesia, Deutsches Herzzentrum, and Institute of Physiology, Freie Universität, Berlin, Germany. Koster@dhzb.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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