Linked Life Data

12354643

Source:http://linkedlifedata.com/resource/pubmed/id/12354643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-9-30
pubmed:abstractText
Nitric oxide (NO) is involved in neuronal transmission by modulating neurotransmitter release in adults and in stabilizing synaptic connections in developing brains. We investigated the influence of downregulation of NO synthesis on oscillatory components of ON and OFF evoked field potentials in the rat superior colliculus. NO synthesis was decreased by inhibiting nitric oxide synthase (NOS) with an acute microinjection of N(omega)-nitro-L-arginine methyl ester (L-NAME). The study focuses on rhythmic activity by analyzing fast Fourier transform (FFT). Collicular responses were recorded in anesthetized rats, at postnatal days (PND) 13-19 and adults. This time window was chosen because it is centered on eye opening. NO downregulation resulted in a dual effect depending on age and response-type. NO synthesis inhibition decreased the magnitude of oscillations in ON responses in the youngest animals (PND13-14), whereas oscillations of frequencies higher than 20 Hz in OFF responses were increased in all age groups of developing rats. In adults NO downregulation increased oscillations in ON responses and decreased oscillations in OFF responses. L-Arginine was used to increase NOS activity and its injection produced effects opposite to those seen with L-NAME. Slow oscillatory components (7-12 Hz) were unaffected in all experiments. Our data together with results reported in the literature suggest that rhythmic patterns of activity are NO-dependent.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-65
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Influence of NO downregulation on oscillatory evoked responses in developing rat superior colliculus.
pubmed:affiliation
Département de Sciences Biologiques, Université de Montréal, C.P. 6128, Succursale centre-ville, Québec, H3C 3J7, Montréal, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't