Source:http://linkedlifedata.com/resource/pubmed/id/12354630
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-9-30
|
| pubmed:abstractText |
To clarify a role of neuronal nitric oxide in neurovascular coupling, we performed cerebral blood flow (CBF) and cerebral metabolic rate of glucose (CMR(glc)) measurements with positron emission tomography in somatosensory-stimulated cats using a specific neuronal nitric oxide synthase inhibitor, 7-nitroindazole (7-NI). The effect on flow-metabolism coupling were tested by global and regional-specific changes on CBF and CMR(glc), and the regional-specific effect was estimated both by regions of interest (ROI) and voxel-based (VB) analysis using globally-normalized CBF and CMR(glc) changes. The electrical somatosensory stimulation in the unilateral forepaw elicited coupled increase in CBF and CMR(glc) in the contralateral somatosensory cortex (7%) and the ipsilateral cerebellum (8%). 7-NI induced 20% decrease in global CBF both during rest and activation, but not in global CMR(glc) at simulation. Both ROI and VB analysis showed that 7-NI induced an increase in CMR(glc) (13%) in the ipsilateral cerebellum compared to control under vehicle alone, but it was accompanied by only 8% increase in CBF, suggesting uncoupling of flow-metabolism while it induced any perturbations in the contralateral somatosensory cortex. These observations suggest that neuronal nitric oxide has an important role for a mediator of regional neurovascular coupling as well as synaptic modulator in the cerebellum, but less so in the neocortex.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/7-nitroindazole,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Indazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0168-0102
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
155-65
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12354630-Animals,
pubmed-meshheading:12354630-Brain Mapping,
pubmed-meshheading:12354630-Cats,
pubmed-meshheading:12354630-Cerebellum,
pubmed-meshheading:12354630-Cerebrovascular Circulation,
pubmed-meshheading:12354630-Electric Stimulation,
pubmed-meshheading:12354630-Energy Metabolism,
pubmed-meshheading:12354630-Enzyme Inhibitors,
pubmed-meshheading:12354630-Functional Laterality,
pubmed-meshheading:12354630-Glucose,
pubmed-meshheading:12354630-Indazoles,
pubmed-meshheading:12354630-Male,
pubmed-meshheading:12354630-Neurons,
pubmed-meshheading:12354630-Nitric Oxide,
pubmed-meshheading:12354630-Nitric Oxide Synthase,
pubmed-meshheading:12354630-Somatosensory Cortex,
pubmed-meshheading:12354630-Synapses,
pubmed-meshheading:12354630-Synaptic Transmission,
pubmed-meshheading:12354630-Tomography, Emission-Computed,
pubmed-meshheading:12354630-Up-Regulation
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Neuronal nitric oxide has a role as a perfusion regulator and a synaptic modulator in cerebellum but not in neocortex during somatosensory stimulation--an animal PET study.
|
| pubmed:affiliation |
Department of Neurology, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. thayashi@ri.nevc.go.jp
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|