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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-9-30
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pubmed:abstractText |
CD4+CD3- cells are the predominant hematopoietic cells found in mouse fetal intestine. We prove their role as Peyer's patch (PP)-inducing cells by transfer into neonatal PP-deficient mice. To test the requirement of chemokines and adhesion molecules in induction of PP, we studied mice deficient in CXCR5 and/or alpha4beta1 integrin-mediated adhesion. CXCR5-/- mice have CD4+CD3- cells, which are inefficient in inducing PP formation. We show here that CXCR5/CXCL13 signaling activates alpha4beta1 integrin on CD4+CD3- cells. Blocking of beta1 integrin or VCAM-1, the ligand of alpha4beta1 integrin, inhibits PP formation. This study demonstrates the link between chemokine receptors and adhesion molecules that regulates stromal/hematopoietic cell interaction leading to PP formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Blr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL13,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcl13 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
363-73
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12354388-Adoptive Transfer,
pubmed-meshheading:12354388-Animals,
pubmed-meshheading:12354388-Antigens, CD3,
pubmed-meshheading:12354388-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12354388-Cell Adhesion,
pubmed-meshheading:12354388-Chemokine CXCL13,
pubmed-meshheading:12354388-Chemokines, CXC,
pubmed-meshheading:12354388-Immunologic Deficiency Syndromes,
pubmed-meshheading:12354388-Integrin alpha4beta1,
pubmed-meshheading:12354388-Mice,
pubmed-meshheading:12354388-Mice, Inbred C57BL,
pubmed-meshheading:12354388-Mice, Knockout,
pubmed-meshheading:12354388-Models, Immunological,
pubmed-meshheading:12354388-Morphogenesis,
pubmed-meshheading:12354388-Peyer's Patches,
pubmed-meshheading:12354388-Radiation Chimera,
pubmed-meshheading:12354388-Receptors, CXCR5,
pubmed-meshheading:12354388-Receptors, Chemokine,
pubmed-meshheading:12354388-Receptors, Cytokine,
pubmed-meshheading:12354388-Signal Transduction,
pubmed-meshheading:12354388-Stromal Cells,
pubmed-meshheading:12354388-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2002
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pubmed:articleTitle |
CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5.
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pubmed:affiliation |
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland. dfinke@isrec.unil.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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