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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-9-27
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pubmed:abstractText |
Association studies of a reportedly functional polymorphism in the promoter region (5'-HTTLPR) of the gene encoding the serotonin transporter protein (genetic locus SLC6A4) in alcoholics have yielded conflicting results. The most frequently observed alleles of the 5'-HTTLPR polymorphism are the short and long variants; the short variant is associated with lower transcriptional activity of the SLC6A4 gene than is the long variant. To reduce the heterogeneity that may confound association studies of alcohol dependence, we examined the association of 5'-HTTLPR alleles with three dichotomous typologies of alcoholism based on sex, comorbid drug dependence, or age of onset of alcohol dependence.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0145-6008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1330-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12351926-Adult,
pubmed-meshheading:12351926-Age of Onset,
pubmed-meshheading:12351926-Alcoholism,
pubmed-meshheading:12351926-Alleles,
pubmed-meshheading:12351926-Carrier Proteins,
pubmed-meshheading:12351926-Comorbidity,
pubmed-meshheading:12351926-Female,
pubmed-meshheading:12351926-Humans,
pubmed-meshheading:12351926-Male,
pubmed-meshheading:12351926-Membrane Glycoproteins,
pubmed-meshheading:12351926-Membrane Transport Proteins,
pubmed-meshheading:12351926-Nerve Tissue Proteins,
pubmed-meshheading:12351926-Polymorphism, Genetic,
pubmed-meshheading:12351926-Promoter Regions, Genetic,
pubmed-meshheading:12351926-Quantitative Trait Loci,
pubmed-meshheading:12351926-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:12351926-Sex Factors,
pubmed-meshheading:12351926-Substance-Related Disorders
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pubmed:year |
2002
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pubmed:articleTitle |
Association study of alcoholism subtypes with a functional promoter polymorphism in the serotonin transporter protein gene.
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pubmed:affiliation |
Department of Psychiatry, Alchohol Research Center, university of Connecticut School of Medicine, Farmington, Connecticult 06030-2103, USA. kranzler@psychiatry.uchc.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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