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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-9-27
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pubmed:abstractText |
Platelet-activating factor (PAF), a phospholipid mediator with a wide range of actions on mature leukocytes, acts through PAF-receptors (PAF-Rs) on the membranes of responsive cells. No results are available concerning the putative presence of PAF-Rs on leukemic blasts. Using multiparameter flow cytometry, we assessed intracellular and membrane PAF-Rs on blast cells of acute myeloid leukemic (AML) and acute lymphoid leukemic (ALL) patients. Membrane PAF-Rs were documented in 7/15 cases of ALL and 0/28 cases of AML. Putative intracellular PAF-Rs were found in blasts of 8/8 ALL and 13/13 AML patients. Vitamin D(3) and dimethyl sulfoxide that induced the expression of PAF-Rs on the membrane of the human promyelocytic leukemia cell line, HL60, failed to induce their expression on the membranes of CD34(+) AML blasts. The lack of membrane PAF-Rs on the membranes of AML blasts confirms that these receptors represent a marker of mature cells and that their membrane induction is a consequence of cell maturation and differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD33 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Activating Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/platelet activating factor receptor
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pubmed:status |
MEDLINE
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pubmed:issn |
1066-5099
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
394-401
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12351810-Acute Disease,
pubmed-meshheading:12351810-Adult,
pubmed-meshheading:12351810-Aged,
pubmed-meshheading:12351810-Antigens, CD,
pubmed-meshheading:12351810-Antigens, CD34,
pubmed-meshheading:12351810-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:12351810-Cell Differentiation,
pubmed-meshheading:12351810-Cell Membrane,
pubmed-meshheading:12351810-Female,
pubmed-meshheading:12351810-Flow Cytometry,
pubmed-meshheading:12351810-Hematopoietic Stem Cells,
pubmed-meshheading:12351810-Humans,
pubmed-meshheading:12351810-Intracellular Fluid,
pubmed-meshheading:12351810-Leukemia, Lymphoid,
pubmed-meshheading:12351810-Leukemia, Myeloid, Acute,
pubmed-meshheading:12351810-Lymphocyte Activation,
pubmed-meshheading:12351810-Male,
pubmed-meshheading:12351810-Platelet Activating Factor,
pubmed-meshheading:12351810-Platelet Membrane Glycoproteins,
pubmed-meshheading:12351810-Receptors, Cell Surface,
pubmed-meshheading:12351810-Receptors, G-Protein-Coupled,
pubmed-meshheading:12351810-Tumor Markers, Biological
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pubmed:year |
2002
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pubmed:articleTitle |
Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia.
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pubmed:affiliation |
UMR CNRS 6101, Service d'Hématologie Clinique, Service de Pédiatrie, CHU Dupuytren, Limoges, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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