Linked Life Data

12351439

Source:http://linkedlifedata.com/resource/pubmed/id/12351439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2002-9-27
pubmed:abstractText
To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1-2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical diabetic autonomic neuropathy (DAN) that eventually occurs in the heart was not present in BB diabetic rats at this early stage as evidenced by normal cardiac VMAT2 immunostaining and normal cardiac norepinephrine content. Also, in contrast to DAN, this islet neuropathy did not worsen with duration of diabetes. These data provide evidence of a heretofore unrecognized early sympathetic islet neuropathy (eSIN). Because eSIN occurs selectively in the islet, is rapid in onset, and is associated with autoimmune but not chemically induced diabetes, it is distinct from DAN in location, time course, and mechanism.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2997-3002
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:12351439-Animals, pubmed-meshheading:12351439-Antibodies, pubmed-meshheading:12351439-Diabetes Mellitus, Type 1, pubmed-meshheading:12351439-Female, pubmed-meshheading:12351439-Islets of Langerhans, pubmed-meshheading:12351439-Male, pubmed-meshheading:12351439-Membrane Glycoproteins, pubmed-meshheading:12351439-Membrane Transport Proteins, pubmed-meshheading:12351439-Nerve Fibers, pubmed-meshheading:12351439-Neuropeptides, pubmed-meshheading:12351439-Oxidopamine, pubmed-meshheading:12351439-Peripheral Nervous System Diseases, pubmed-meshheading:12351439-Rats, pubmed-meshheading:12351439-Rats, Inbred BB, pubmed-meshheading:12351439-Sympathectomy, Chemical, pubmed-meshheading:12351439-Sympathetic Nervous System, pubmed-meshheading:12351439-Sympatholytics, pubmed-meshheading:12351439-Vesicular Biogenic Amine Transport Proteins, pubmed-meshheading:12351439-Vesicular Monoamine Transport Proteins
pubmed:year
2002
pubmed:articleTitle
Early, selective, and marked loss of sympathetic nerves from the islets of BioBreeder diabetic rats.
pubmed:affiliation
Division of Endocrinology and Metabolism, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA. qmei@u.washington.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't