Linked Life Data

12350512

Source:http://linkedlifedata.com/resource/pubmed/id/12350512

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-9-27
pubmed:abstractText
To evaluate the expression of the coxsackie and adenovirus receptor (CAR) and alpha(v) integrins in clinical specimens of bladder cancer to determine the susceptibility to adenoviral gene therapy. Efficient adenovirus-based gene therapy requires binding of the virus to CAR and involves the alpha(v) integrins. Studies on bladder cancer cell lines have shown that low adenoviral transduction rates were associated with low-level expression of CAR. Integrin alpha(v) expression increases in various tumors suggest its importance in differentiation, proliferation, and migration. CAR is structurally a member of the Ig-type superfamily of cell-cell adhesion molecules, suggesting that its expression may also be related to the state of tumor differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1527-9995
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-6
pubmed:dateRevised
2011-7-1
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer.
pubmed:affiliation
Brady Urological Institute, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't