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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1977-1-25
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pubmed:abstractText |
A murine tumor-associated alpha-globulin was identified by immunofluorescence, cytotoxicity, and immunoelectrophoresis. The antiserum resulting from heterologous immunization with the segregated antigen was tolerated in multiple injections and was therapeutic; host cell participation by macrophages and lymphocytes led to the therapeutic result. Investigation of human ovarian carcinoma demonstrated an alpha-globulin which shares antigenic specificity with other tumor-associated antigens. The successful scanning of a tumor mass with a heterologous antibody directed against a tumor-associated antigen demonstrated the feasibility of applying these techniques to clinical cancer.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0083-1921
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-43
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1234634-Animals,
pubmed-meshheading:1234634-Antigens, Neoplasm,
pubmed-meshheading:1234634-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:1234634-Female,
pubmed-meshheading:1234634-Immune Sera,
pubmed-meshheading:1234634-Immunization, Passive,
pubmed-meshheading:1234634-Immunotherapy,
pubmed-meshheading:1234634-Lectins,
pubmed-meshheading:1234634-Lymphocyte Activation,
pubmed-meshheading:1234634-Mice,
pubmed-meshheading:1234634-Mice, Inbred C3H,
pubmed-meshheading:1234634-Neoplasms, Experimental,
pubmed-meshheading:1234634-Ovarian Neoplasms
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pubmed:year |
1975
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pubmed:articleTitle |
Ovarian tumor antigens: a new potential for therapy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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