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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1976-12-3
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pubmed:abstractText |
Offspring of rats treated with 2 mg/kg body weight chlorpromazine (CPZ) on Days 5-8 of gestation had lower seizure thresholds than offspring of saline-treated controls at 30, 60, 90, and 120 days of age. The CPZ-treated offspring were also heavier than controls prior to weaning. Further analysis using cross-fostered litters indicated that at least part of the drug effect on seizure thresholds took place before birth, although a postnatal component was also demonstrated. A striking effect of the fostering experience itself on the seizure threshold prevented conclusions about the relative importance of prenatal and postnatal influences.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0012-1630
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1233328-Age Factors,
pubmed-meshheading:1233328-Animals,
pubmed-meshheading:1233328-Animals, Newborn,
pubmed-meshheading:1233328-Body Weight,
pubmed-meshheading:1233328-Chlorpromazine,
pubmed-meshheading:1233328-Differential Threshold,
pubmed-meshheading:1233328-Female,
pubmed-meshheading:1233328-Flurothyl,
pubmed-meshheading:1233328-Gestational Age,
pubmed-meshheading:1233328-Litter Size,
pubmed-meshheading:1233328-Male,
pubmed-meshheading:1233328-Maternal-Fetal Exchange,
pubmed-meshheading:1233328-Pregnancy,
pubmed-meshheading:1233328-Rats,
pubmed-meshheading:1233328-Reaction Time,
pubmed-meshheading:1233328-Seizures,
pubmed-meshheading:1233328-Sex Factors
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pubmed:year |
1975
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pubmed:articleTitle |
Effects of testing age and fostering experience on seizure susceptibility of rats treated prenatally with chlorpromazine.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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