Linked Life Data

1233267

Source:http://linkedlifedata.com/resource/pubmed/id/1233267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1976-12-1
pubmed:abstractText
The pharmacokinetics of quercetin, a flavonoid, have been studied in 6 volunteers after single intravenous (100 mg) and oral (4 g) doses. The data after iv administration were analyzed according to a two compartment open model with half lives of 8.8 +/- 1.2 min for the alpha phase and 2.4 +/- 0.2 h for the beta phase (predominant half life), respectively. Protein binding was greater than 98%. The apparent volume of distribution was small at 0.34 +/- 0.03 1/kg. Of the intravenous dose 7.4 +/- 1.2% was excreted in urine as a conjugated metabolite, and 0.65 +/- 0.1% was excreted unchanged. After oral administration no measurable plasma concentrations could be detected, nor was any quercetin found in urine, either unchanged or in a metabolized form. These results exclude absorption of more than 1% of unchanged drug. Recovery in faeces after the oral dose was 53 +/- 5%, which suggests extensive degradation by microorganisms in the gut. The data obtained show that oral administration of flavonoids may be of questionable value.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0031-6970
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Disposition of quercetin in man after single oral and intravenous doses.
pubmed:publicationType
Journal Article, Comparative Study