Linked Life Data

12320650

Source:http://linkedlifedata.com/resource/pubmed/id/12320650

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-5-5
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
J
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:volume
7
pubmed:owner
PIP
pubmed:pagination
4-13
pubmed:dateRevised
2003-11-14
pubmed:otherAbstract
PIP: Substantial changes have occurred over the last three decades in the dose and type of both the estrogen and progestin components of oral contraceptives (OCs) and the sequencing or phasing of these steroids. The current generation of low-dose OCs was made possible by the finding that estrogen and progestins act synergistically to inhibit the pituitary. By October 1996, low-dose OCs accounted for 98% of all retail OC sales in the US. The present trend is toward the development of monophasic OCs containing only 20 mcg of ethinyl estradiol, a dose that retains efficacy. Although OCs containing norgestrel and levonorgestrel are associated with a lower incidence of breakthrough bleeding and spotting, cycle control problems tend to disappear after a few months of use regardless of formulation. Recent clinical research suggests that OC-induced lipid changes do not accelerate the development of atherosclerotic cardiovascular disease and may, in fact, provide protection against atherosclerotic plaque development. The limited data available on retention of OC-related beneficial health effects with 20 mcg preparations indicate ovarian cyst development may be the only affected parameter. Moreover, the decreased estrogen may improve protection against endometrial cancer. Although it is anticipated that 20 mcg OCs will become the first-line choice for most women, these formulations will have special benefits for adolescents and perimenopausal women.
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Trends in oral contraceptive development and utilization: looking to the future.
pubmed:publicationType
Journal Article