Linked Life Data

1231939

Source:http://linkedlifedata.com/resource/pubmed/id/1231939

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1976-10-20
pubmed:abstractText
Two days after a single intraperitoneal injection of cyclophosphamide (CY) in a dose of 300 mg/kg of body weight, the cellularity of the thymus from adult female CBA mice was reduced to 17% of its normal value. The electrophoretic mobility (EPM) analysis of the surviving cells revealed a decrease in the proportion of the slow-moving cells together with a significant diminution of their mean EPM. The proportion of fast-moving cells, which were shown to correspond to the hydrocortisone-resistant and mitogen-responsive pool of mature thymocytes, was correlatively increased by 2-3 fold. Despite this enrichment in cells with a high surface charge, the thymocytes from CY-treated mice exhibited a diminished reactivity "in vitro" to both concanavalin A and phytohemagglutinin. The possible significance of theses results is discussed with reference to the known mitostatic properties of CY.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0300-0893
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Effect of treatment with cyclophosphamide on the electrophoretic mobility and mitogen responsiveness of mouse thymus cells.
pubmed:publicationType
Journal Article