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pubmed:otherAbstract |
PIP: Hepatic side effects of a combined oral contraceptive (norethinodrel 4.925 mg and mestranol .075) were studied in 18 women aged 24-41 years. Blood cholesterol values, although remaining within normal limits, tended to diminish, apparently confirming the hypocholesteremic effect noted by other authors. Total serum protein, albumin, alpha-, beta-, and gamma-globulins, serum bilirubin, serum glutamic oxalacetic transaminase and serum glutamic pyruvic transaminase were essentially unchanged after 3 and 6 months of treatment. Thus, hepatic damage can be ruled out in the small group treated. On the basis of other reports, however, oral contraceptive use by women with a history of liver disease or of jaundice or pruritus during pregnancy is not recommended.
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