Linked Life Data

1229996

Source:http://linkedlifedata.com/resource/pubmed/id/1229996

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1976-8-23
pubmed:abstractText
The antibiotic levels in patients suffering from angina were studied with the agar-diffusion method. The drugs were used orally in single and multiple doses (every 6 hours): erythromycin in doses of 4000 and 6000 gamma/kg and oleandomycin in doses of 4000 and 8000 gamma/kg. When erythromycin was used in a single dose of 4000 gamma/kg, its levels in the objects tested, i.e. the blood serum, saliva, mucus from the tonsil surface and tissue did not reach the concentrations corresponding to the sensitivity levels of the microbes to the antibiotic (0.75 gamma/ml). When the drug was used every 6 hours, the concentration increased. Still, it reached the above level only in the blood and tonsil surface mucus. Only when the antibiotic was used repeatedly in doses of 6000 gamma/kg, its levels in the examined objects reached 0.75 gamma/ml. When oleandomycin was used in single and repeated doses of 4000 gamma/kg, its levels were always lower than those providing sensitivity of beta-hemolytic streptococci to it (1.0 gamma/ml). The antibiotic use in doses of 8000 gamma/kg provided the required level in all the object examined.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-5637
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
[Erythromycin and oleandomycin concentration in the body of angina patients taking the preparations orally].
pubmed:publicationType
Journal Article, English Abstract