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pubmed:abstractText |
Hydroxylation of norethisterone by a large number of fungi has been investigated. 1alpha-Hydroxy-, 6beta-hydroxy-, 10beta-hydroxy-, 10beta,11beta-dihydroxy-15alpha-and 15beta-hydroxy-derivatives were formed from norethisterone. The microbiological dehydrogenation of 10beta-hydroxy-norethisterone resulting in 10beta,17beta-dihydroxy-17-ethynyl-1,4-estradien-3-one was also observed. The structure of transformation products was established by chemical and spectroscopical methods.
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pubmed:otherAbstract |
PIP: The microbiological hydroxylation of noresthisterone (17-ethynyl-17b eta-hydroxy-4-estren-3-one) is reported. 1 alpha-hydroxy-,6 beta-hydroxy-, 10 beta-hydroxy-, 6 beta,10 beta-dihydroxy-, 10 beta,11 beta dihydroxy-15 alpha and 15 beta-hydroxy-derivatives were formed from norethisterone by a large number of fungi. The dehydrogenation of 10 beta-hydroxy-norethisterone resulted in 10 beta,17 beta-dihydroxy-17-ethynyl-1,4-estradien-3-one. Chemical and spectroscopical methods were employed to establish the structure of the transformation products.
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