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rdf:type |
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lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0003451,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0072780,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0243076,
umls-concept:C0387687,
umls-concept:C0441655,
umls-concept:C1883254,
umls-concept:C2349975
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pubmed:issue |
20
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pubmed:dateCreated |
2002-9-24
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pubmed:abstractText |
A series of alpha-(pyrrolidin-1-yl)acetic acids is presented as selective and potent antivirals against HIV. Several of the pyrrolidine zwitterions demonstrated reasonable in vitro properties, enhanced antiviral activities and improved pharmacokinetic profiles over pyrrolidine 1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BudhuRichard JRJ,
pubmed-author:CarellaAnthonyA,
pubmed-author:CarverGwenG,
pubmed-author:CascieriMargaret AMA,
pubmed-author:ChapmanKevin TKT,
pubmed-author:DanzeisenReneeR,
pubmed-author:DeMartinoJulie AJA,
pubmed-author:EminiEmilio AEA,
pubmed-author:GentryAmy LAL,
pubmed-author:GouldSandra LSL,
pubmed-author:HaleJeffrey JJJ,
pubmed-author:HazudaDariaD,
pubmed-author:HolmesKarenK,
pubmed-author:KesslerJosephJ,
pubmed-author:LinebergerJanetJ,
pubmed-author:LynchChristopher LCL,
pubmed-author:MacCossMalcolmM,
pubmed-author:MalkowitzLorraineL,
pubmed-author:MillerMichaelM,
pubmed-author:MillsSander GSG,
pubmed-author:SchleifWilliam AWA,
pubmed-author:SicilianoSalvatore JSJ,
pubmed-author:SpringerMartin SMS
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3001-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12270193-Animals,
pubmed-meshheading:12270193-Anti-HIV Agents,
pubmed-meshheading:12270193-CHO Cells,
pubmed-meshheading:12270193-Cell Membrane Permeability,
pubmed-meshheading:12270193-Chemistry, Physical,
pubmed-meshheading:12270193-Chemokine CCL4,
pubmed-meshheading:12270193-Cricetinae,
pubmed-meshheading:12270193-HIV-1,
pubmed-meshheading:12270193-HeLa Cells,
pubmed-meshheading:12270193-Humans,
pubmed-meshheading:12270193-Indicators and Reagents,
pubmed-meshheading:12270193-Macrophage Inflammatory Proteins,
pubmed-meshheading:12270193-Physicochemical Phenomena,
pubmed-meshheading:12270193-Pyrrolidines,
pubmed-meshheading:12270193-Rats,
pubmed-meshheading:12270193-Receptors, CCR5,
pubmed-meshheading:12270193-Structure-Activity Relationship
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pubmed:year |
2002
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pubmed:articleTitle |
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. chris_lynch@merck.com
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pubmed:publicationType |
Journal Article
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