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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2002-9-24
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pubmed:abstractText |
Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2863-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12270164-Animals,
pubmed-meshheading:12270164-Blood Pressure,
pubmed-meshheading:12270164-Brain,
pubmed-meshheading:12270164-Brain Ischemia,
pubmed-meshheading:12270164-Cyclic GMP,
pubmed-meshheading:12270164-Dose-Response Relationship, Drug,
pubmed-meshheading:12270164-Guanylate Cyclase,
pubmed-meshheading:12270164-Infarction, Middle Cerebral Artery,
pubmed-meshheading:12270164-Muscle, Smooth, Vascular,
pubmed-meshheading:12270164-Muscle Relaxation,
pubmed-meshheading:12270164-Neuroprotective Agents,
pubmed-meshheading:12270164-Nitrates,
pubmed-meshheading:12270164-Nitroglycerin,
pubmed-meshheading:12270164-Propane,
pubmed-meshheading:12270164-Rats,
pubmed-meshheading:12270164-Vasodilator Agents
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pubmed:year |
2002
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pubmed:articleTitle |
Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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