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pubmed:otherAbstract |
PIP: Development of spermatogenesis in hypogonadism is discussed. Case r eports are presented of 4 patients in whom spermatogenesis appeared to have been the result of treatment and 1 patient in which it seemed likel y that fertility might have been present but after disappearing, was not restored a 2nd time during the period of observation. An excess of follicle stimulating hormone (FSH) was not found in any of the patients, therefore it was assumed that the primary disturbance was not in the testis, at least not in the tubular portions. It is concluded that treatment with testosterone alone may bring about development of secondary sex characteristics and spermatogenesis in some cases of hypogonadotropic eunchoidism or panhypopituitarism in the male. Chorionic gonadotropin with varying quantities of FSH may bring about development of secondary sex characteristics and nitrogen retention through stimulation of the Leydig cells. Apparently once these developments have occurred, continued treatment is not always necessary.
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