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pubmed:otherAbstract |
PIP: The effects of a new synthetic progestagen (3beta,17alpha diacetoxy 6chloro-pregnene-4, used experimentally in large doses in the treatment of endometrial carcinoma on the oral mucosa, were studied in 8 patients. Cytological changes were very similar to those found in the vagina after progesterone administration; the antimaturative effect of the gestagen was also visible in oral smears. The constant increase observed in the number of cells with eosinophilic cytoplasm suggests that some other factors may be operating indirectly; this factor could be the saliva, which may undergo changes due to the effects of the gestagen.
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