Linked Life Data

12244566

Source:http://linkedlifedata.com/resource/pubmed/id/12244566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-9-23
pubmed:abstractText
Thyrotropin-releasing hormone (TRH) may stimulate lactotrophs to increase intracellular Ca(2+) and to secrete prolactin (PRL). In this study, PRL contents in lactotrophs were determined by the sequential cell immunoblot assay (SCIBA) and their changes in intracellular Ca(2+) was analyzed by confocal microscopy. Significant correlations were found in the corresponding parameters between TRH treatments with a recovery interval of 2 h. Measuring the PRL contents after the first TRH treatment and then determining the intracellular Ca(2+) changes after the second TRH treatment revealed four lactotroph subpopulations. Type I cells (51%) showed significant responses of both PRL secretion and intracellular Ca(2+) concentration. Type II cells (22%) increased in PRL secretion, but without changes in intracellular Ca(2+). Type III cells (17%) have increased in intracellular Ca(2+), but without changes in PRL secretion. Type IV cells (10%) did not show changes in PRL secretion and intracellular Ca(2+).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0730-2312
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Prolactin secretion and intracellular Ca(2+) change in rat lactotroph subpopulations stimulated by thyrotropin-releasing hormone.
pubmed:affiliation
Institute of Biochemistry, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't