| pubmed-article:12244163 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C0002390 | lld:lifeskim |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C0025927 | lld:lifeskim |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C0242568 | lld:lifeskim |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:12244163 | lifeskim:mentions | umls-concept:C1257757 | lld:lifeskim |
| pubmed-article:12244163 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12244163 | pubmed:dateCreated | 2002-9-23 | lld:pubmed |
| pubmed-article:12244163 | pubmed:abstractText | Previously, we have shown in a model of hypersensitivity pneumonitis that Th1-biased C57BL/6 mice are susceptible and Th2-biased DBA/2 mice are resistant to disease. We also showed that this was explained in part by differential regulation of IL-12 by IL-4. For these reasons, we postulated that C57BL/6 and DBA/2 mice differentially express IL-4. In this study, we show that C57BL/6 immune cells express Th2 but not Th1 cytokines at lower levels than DBA/2 cells. We also found that C57BL/6 splenocytes exhibit decreased mRNA stability of Th2 cytokines, relative to DBA/2 splenocytes. Stability of IL-2 and IFN-gamma were similar in the two strains of mice. Differences in Th2 cytokine mRNA stability between C57BL/6 and DBA/2 cells were not due to sequence polymorphism at specific regions of the IL-4/IL-13 locus. Furthermore, expression of Th1- and Th2-specific transcription factors T-bet and GATA-3, as well as the nuclear factor of activated T cells transcription factor, NFATc, was not significantly different between the two mice. Our data suggest that decreased mRNA stability of Th2 cytokines in C57BL/6 splenocytes may underlie the differential susceptibility to hypersensitivity pneumonitis between C57BL/6 and DBA/2 mice. Moreover, our results indicate that regulation of mRNA stability may serve as an important mechanism underlying Th1/Th2 immune polarization. | lld:pubmed |
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| pubmed-article:12244163 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244163 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12244163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244163 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12244163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12244163 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12244163 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12244163 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12244163 | pubmed:author | pubmed-author:MonickMartha... | lld:pubmed |
| pubmed-article:12244163 | pubmed:author | pubmed-author:HunninghakeGa... | lld:pubmed |
| pubmed-article:12244163 | pubmed:author | pubmed-author:ButlerNoah... | lld:pubmed |
| pubmed-article:12244163 | pubmed:author | pubmed-author:YarovinskyTim... | lld:pubmed |
| pubmed-article:12244163 | pubmed:author | pubmed-author:PowersLinda... | lld:pubmed |
| pubmed-article:12244163 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12244163 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12244163 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:12244163 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12244163 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12244163 | pubmed:pagination | 3700-9 | lld:pubmed |
| pubmed-article:12244163 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12244163 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12244163 | pubmed:articleTitle | Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. | lld:pubmed |
| pubmed-article:12244163 | pubmed:affiliation | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242, USA. noah-butler@uiowa.edu | lld:pubmed |
| pubmed-article:12244163 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12244163 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12244163 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12244163 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12244163 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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