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rdf:type |
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lifeskim:mentions |
umls-concept:C0010531,
umls-concept:C0017337,
umls-concept:C0024141,
umls-concept:C0026882,
umls-concept:C0039194,
umls-concept:C0041904,
umls-concept:C0162493,
umls-concept:C0220905,
umls-concept:C1519595,
umls-concept:C1711351,
umls-concept:C2003941
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pubmed:issue |
9336
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pubmed:dateCreated |
2002-9-23
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pubmed:abstractText |
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterised by diverse dysfunctions of immune effector cells, including proliferation and cytotoxicity. In T cells from patients with SLE, activity of type 1 protein kinase A isozymes is greatly reduced because of decreased expression of the alpha and beta regulatory subunits (RI alpha and RI beta). We aimed to identify a molecular mechanism or mechanisms for this isozyme deficiency by assessing occurrence of mutations in transcripts of the RI alpha subunit in patients with SLE.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Deaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/PRKAR1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Induced Silencing Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/dsRNA adenosine deaminase
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
360
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
842-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12243919-Adenosine Deaminase,
pubmed-meshheading:12243919-Adult,
pubmed-meshheading:12243919-Base Sequence,
pubmed-meshheading:12243919-Cohort Studies,
pubmed-meshheading:12243919-Cyclic AMP-Dependent Protein Kinase RIalpha Subunit,
pubmed-meshheading:12243919-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:12243919-DNA, Complementary,
pubmed-meshheading:12243919-DNA Mutational Analysis,
pubmed-meshheading:12243919-Female,
pubmed-meshheading:12243919-Gene Expression,
pubmed-meshheading:12243919-Gene Frequency,
pubmed-meshheading:12243919-Humans,
pubmed-meshheading:12243919-Lupus Erythematosus, Systemic,
pubmed-meshheading:12243919-Male,
pubmed-meshheading:12243919-Mutation,
pubmed-meshheading:12243919-RNA, Messenger,
pubmed-meshheading:12243919-RNA Editing,
pubmed-meshheading:12243919-RNA-Induced Silencing Complex,
pubmed-meshheading:12243919-Ribonucleoproteins,
pubmed-meshheading:12243919-T-Lymphocytes,
pubmed-meshheading:12243919-Transcription, Genetic,
pubmed-meshheading:12243919-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes.
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pubmed:affiliation |
Section on Rheumatology and Clinical Immunology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. dlaxmina@wfubmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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