Source:http://linkedlifedata.com/resource/pubmed/id/12242484
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-9-20
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| pubmed:abstractText |
The aim of this study was to determine the spatial and temporal expression of various pro-inflammatory cytokines in the peri-sinoatrial nodal area after atrial infarction. Rats were subjected to permanent atrial infarction, in particular, sinoatrial node (SAN) infarction and sacrificed at various time points up to 7 days. Real-time polymerase chain reaction analysis demonstrated that mRNA levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta, interleukin-6, and transforming growth factor beta 1 (TGF-beta(1)) were upregulated in the peri-sinoatrial nodal area after atrial infarction. Immunostaining for TNF-alpha and TGF-beta(1) proteins revealed that both cytokines were expressed persistently up to 7 days after atrial infarction around the peri-sinoatrial nodal area. Furthermore, the infiltrating inflammatory cells immunoreactive for both cytokines were predominant within the infarct SAN. In situ hybridization analysis showed that TNF-alpha gene expression was enhanced in the inflammatory cells and myocardium within the peri-sinoatrial nodal area in response to the infarction. These results provide evidence for the local expression of cytokines in the post-ischemic peri-sinoatrial nodal area, suggesting that the upregulation of the cytokines might be associated with the atrial arrhythmia observed after acute myocardial infarction.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0302-766X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
310
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
59-66
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12242484-Animals,
pubmed-meshheading:12242484-Arrhythmia, Sinus,
pubmed-meshheading:12242484-Chemotaxis, Leukocyte,
pubmed-meshheading:12242484-Cytokines,
pubmed-meshheading:12242484-Disease Models, Animal,
pubmed-meshheading:12242484-Female,
pubmed-meshheading:12242484-Gene Expression,
pubmed-meshheading:12242484-Immunohistochemistry,
pubmed-meshheading:12242484-Interleukin-1,
pubmed-meshheading:12242484-Interleukin-6,
pubmed-meshheading:12242484-Male,
pubmed-meshheading:12242484-Myocardial Ischemia,
pubmed-meshheading:12242484-RNA, Messenger,
pubmed-meshheading:12242484-Rats,
pubmed-meshheading:12242484-Rats, Wistar,
pubmed-meshheading:12242484-Sinoatrial Node,
pubmed-meshheading:12242484-Time Factors,
pubmed-meshheading:12242484-Transforming Growth Factor beta,
pubmed-meshheading:12242484-Transforming Growth Factor beta1,
pubmed-meshheading:12242484-Tumor Necrosis Factor-alpha
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| pubmed:year |
2002
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| pubmed:articleTitle |
Induction of cytokine expression in rat post-ischemic sinoatrial node (SAN).
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| pubmed:affiliation |
Department of Anatomy, Faculty of Medicine, National University of Singapore, Lower Kent Ridge Road, Singapore 117597.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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