Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2002-9-20
pubmed:abstractText
Chromosomal translocation t(9;11)(p22;q23) in acute myeloid leukemia fuses the MLL and AF9 genes. We have inactivated the murine homologue of AF9 to elucidate its normal role. No effect on hematopoiesis was observed in mice with a null mutation of Af9. However, an Af9 null mutation caused perinatal lethality, and homozygous mice exhibited anomalies of the axial skeleton. Both the cervical and thoracic regions were affected by anterior homeotic transformation. Strikingly, mice lacking functional Af9 exhibited a grossly deformed atlas and an extra cervical vertebra. To determine the molecular mediators of this phenotype, analysis of Hox gene expression by in situ hybridization showed that Af9 null embryos have posterior changes in Hoxd4 gene expression. We conclude that the Af9 gene is required for normal embryogenesis in mice by controlling pattern formation, apparently via control of Hox gene regulation. This is analogous to the role of Mll, the murine homolog of human MLL, to which the Af9 gene fuses in acute myeloid leukemias.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-10023690, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-10393173, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-10516753, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-10887138, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-10905048, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-11313972, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-1303259, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-1346368, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-1358593, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-1372255, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-1423624, http://linkedlifedata.com/resource/pubmed/commentcorrection/12242306-1423625, 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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/HOXD10 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Hoxd4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/MLL protein, human, http://linkedlifedata.com/resource/pubmed/chemical/MLLT3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Mll protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Mllt3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0270-7306
pubmed:author
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