rdf:type |
|
lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0006938,
umls-concept:C0008976,
umls-concept:C0026538,
umls-concept:C0026565,
umls-concept:C0027051,
umls-concept:C0030705,
umls-concept:C0126174,
umls-concept:C0155626,
umls-concept:C0231491,
umls-concept:C1280500,
umls-concept:C2698651
|
pubmed:issue |
9335
|
pubmed:dateCreated |
2002-9-20
|
pubmed:abstractText |
ACE inhibitors attenuate the detrimental effects of angiotensin II, and improve survival and reduce morbidity in patients with acute myocardial infarction and evidence of heart failure or left-ventricular dysfunction. Selective antagonism of the angiotensin type 1 receptor represents an alternative approach to inhibition of the renin-angiotensin system. We did a multicentre, randomised trial to test the hypothesis that the angiotensin II antagonist losartan would be superior or non-inferior to the ACE inhibitor captopril in decreasing all-cause mortality in high-risk patients after acute myocardial infarction.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0140-6736
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
7
|
pubmed:volume |
360
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
752-60
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12241832-Aged,
pubmed-meshheading:12241832-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:12241832-Antihypertensive Agents,
pubmed-meshheading:12241832-Captopril,
pubmed-meshheading:12241832-Endpoint Determination,
pubmed-meshheading:12241832-Female,
pubmed-meshheading:12241832-Humans,
pubmed-meshheading:12241832-Losartan,
pubmed-meshheading:12241832-Male,
pubmed-meshheading:12241832-Middle Aged,
pubmed-meshheading:12241832-Morbidity,
pubmed-meshheading:12241832-Myocardial Infarction,
pubmed-meshheading:12241832-Risk Factors
|
pubmed:year |
2002
|
pubmed:articleTitle |
Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan.
|
pubmed:affiliation |
University of Bergen, Cardiology Division, Central Hospital in Rogaland, 4011 Stavanger, Norway. trout.@online.no
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|