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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0019704,
umls-concept:C0031437,
umls-concept:C0031715,
umls-concept:C0078911,
umls-concept:C0174680,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0334094,
umls-concept:C0441712,
umls-concept:C1328818,
umls-concept:C1880177,
umls-concept:C2911684
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pubmed:dateCreated |
2003-2-6
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pubmed:abstractText |
The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium to exit quiescence are largely unknown. Here, we ask whether the expression of HIV-1 genes in infected podocytes induces cyclin D1 and phospho-pRb (Ser780) expression, hallmarks of cyclin D1-mediated G1-->S phase progression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10050090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10359590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10616834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10751212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10779339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10886558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10886562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10906320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-10916090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11056537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11063931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11179239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11431468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11461940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11481487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11495003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11533201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11729253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11841621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-11994743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-12089376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-1542649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-1926769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-6663985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-7996798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-8175885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-8491378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9003781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9202060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9344605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9603954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9759480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9770555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9792703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12241561-9890309
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1471-2180
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26
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pubmed:dateRevised |
2010-4-29
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pubmed:meshHeading |
pubmed-meshheading:12241561-AIDS-Associated Nephropathy,
pubmed-meshheading:12241561-Animals,
pubmed-meshheading:12241561-Cell Cycle,
pubmed-meshheading:12241561-Cells, Cultured,
pubmed-meshheading:12241561-Cyclin D1,
pubmed-meshheading:12241561-G1 Phase,
pubmed-meshheading:12241561-HIV-1,
pubmed-meshheading:12241561-Mice,
pubmed-meshheading:12241561-Phenotype,
pubmed-meshheading:12241561-Phosphorylation,
pubmed-meshheading:12241561-Retinoblastoma Protein,
pubmed-meshheading:12241561-S Phase,
pubmed-meshheading:12241561-Serine
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pubmed:year |
2002
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pubmed:articleTitle |
HIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy.
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pubmed:affiliation |
Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA. peter.nelson@mssm.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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