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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-9-20
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pubmed:abstractText |
Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A-inhibited oxygen consumption in the high-oxygen range. This suggests an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen affinity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression of oxygen pressure induces energetic stress under hypoxia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-4851
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12241081-Antimycin A,
pubmed-meshheading:12241081-Cell Respiration,
pubmed-meshheading:12241081-Cells, Cultured,
pubmed-meshheading:12241081-Fibroblasts,
pubmed-meshheading:12241081-Humans,
pubmed-meshheading:12241081-Oligomycins,
pubmed-meshheading:12241081-Oxygen,
pubmed-meshheading:12241081-Oxygen Consumption,
pubmed-meshheading:12241081-Rotenone,
pubmed-meshheading:12241081-Uncoupling Agents
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pubmed:year |
2002
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pubmed:articleTitle |
Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption.
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pubmed:affiliation |
Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck.
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pubmed:publicationType |
Journal Article
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