Source:http://linkedlifedata.com/resource/pubmed/id/12239213
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2002-11-26
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pubmed:abstractText |
The biophysical properties of small conductance Ca(2+)-activated K(+) (SK) channels are well suited to underlie afterhyperpolarizations (AHPs) shaping the firing patterns of a conspicuous number of central and peripheral neurons. We have identified a new scorpion toxin (tamapin) that binds to SK channels with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. This toxin distinguished between the SK channels underlying the apamin-sensitive I(AHP) and the Ca(2+)-activated K(+) channels mediating the slow I(AHP) (sI(AHP)) in hippocampal neurons. Compared with related scorpion toxins, tamapin displayed a unique, remarkable selectivity for SK2 versus SK1 ( approximately 1750-fold) and SK3 ( approximately 70-fold) channels and is the most potent SK2 channel blocker characterized so far (IC(50) for SK2 channels = 24 pm). Tamapin will facilitate the characterization of the subunit composition of native SK channels and help determine their involvement in electrical and biochemical signaling.
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pubmed:language |
eng
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apamin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Scorpion Venoms
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pubmed:status |
MEDLINE
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pubmed:author |
pubmed-author:D'hoedtDieterD,
pubmed-author:DoortyKevina BKB,
pubmed-author:GadreS VSV,
pubmed-author:JeyaseelanKandiahK,
pubmed-author:JosephJeremiah SJS,
pubmed-author:KiniR ManjunathaRM,
pubmed-author:PedarzaniPaolaP,
pubmed-author:SapatnekarS MSM,
pubmed-author:StockerMartinM,
pubmed-author:StrongPeter NPN,
pubmed-author:WadsworthJonathan D FJD
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46101-9
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pubmed:dateRevised |
2006-11-15
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pubmed:articleTitle |
Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons.
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pubmed:affiliation |
Department of Physiology, University College London, London WC1E 6BT, United Kingdom.
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