Linked Life Data

12237185

Source:http://linkedlifedata.com/resource/pubmed/id/12237185

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2002-9-18
pubmed:abstractText
The effect on the nociceptive tail-flick (TF) reflex of cardiopulmonary chemoreceptor and arterial baroreceptor activation, producing Bezold-Jarisch like- and baro-reflex responses, respectively, was analysed in lightly halothane-anaesthetized rats. Intra-cardiac administration of phenylbiguanide (5-100 microg/kg, into the right atrium) or veratrine (30-150 microg/kg, into the left ventricle), which both elicited the characteristic Bezold-Jarisch-like cardiovascular reflex responses (hypotension and bradycardia), produced a dose-dependent increase in TF latency. A similar inhibitory influence on the TF reflex was noted upon baroreflex activation by acute administration of phenylephrine (15-50 microg/kg i.v.) or aortic depressor nerve stimulation (100-400 microA). As expected from the involvement of local excitatory amino acid receptors in both vagally mediated cardiovascular reflex responses and inhibition of the TF reflex, microinjections of kynurenic acid (3 nmol/0.1 microl), an N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonist, into the nucleus tractus solitarius, prevented the cardiovascular responses as well as the concomitant increase in TF latency produced by cardiopulmonary chemoreceptor and baroreceptor stimulations. The present data show that induction of the cardiopulmonary chemoreceptor and baroreceptor reflexes produces an antinociceptive effect which can be assessed using the TF test, and that glutamate ionotropic receptors within the nucleus tractus solitarius mediate this effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0304-3959
pubmed:author
pubmed:copyrightInfo
Copyright 2002 International Association for the Study of Pain
pubmed:issnType
Print
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-81
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12237185-Analgesics, pubmed-meshheading:12237185-Animals, pubmed-meshheading:12237185-Aorta, pubmed-meshheading:12237185-Atropine, pubmed-meshheading:12237185-Baroreflex, pubmed-meshheading:12237185-Biguanides, pubmed-meshheading:12237185-Chemoreceptor Cells, pubmed-meshheading:12237185-Electric Stimulation, pubmed-meshheading:12237185-Excitatory Amino Acid Antagonists, pubmed-meshheading:12237185-Kynurenic Acid, pubmed-meshheading:12237185-Male, pubmed-meshheading:12237185-Nociceptors, pubmed-meshheading:12237185-Parasympatholytics, pubmed-meshheading:12237185-Phenylephrine, pubmed-meshheading:12237185-Rats, pubmed-meshheading:12237185-Rats, Sprague-Dawley, pubmed-meshheading:12237185-Skin Temperature, pubmed-meshheading:12237185-Solitary Nucleus, pubmed-meshheading:12237185-Sympathomimetics, pubmed-meshheading:12237185-Tail, pubmed-meshheading:12237185-Veratrine
pubmed:year
2002
pubmed:articleTitle
Antinociceptive effect of cardiopulmonary chemoreceptor and baroreceptor reflex activation in the rat.
pubmed:affiliation
Neuropsychopharmacologie Moléculaire, Cellulaire et Fonctionnelle (INSERM U288), CHU Pitié-Salpêtrière, 91 Boulevard de l'Hôpital, 75634 Paris Cedex 13, France. sevoz@ext.jussieu.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't