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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-9-18
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pubmed:abstractText |
Co-expression of the KvLQT1 and minK potassium channel subunits is required to recapitulate I(Ks), the slow component of the cardiac delayed rectifier current, and mutations in either gene cause the congenital Long QT syndrome. It is becoming increasingly well-recognized that multiprotein channel complexes containing proteins capable of modulating channel function assemble at the plasma membrane. Thus, the aim of our study was to identify proteins involved in I(Ks) modulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-103
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12237170-Animals,
pubmed-meshheading:12237170-CHO Cells,
pubmed-meshheading:12237170-Cell Membrane,
pubmed-meshheading:12237170-Cricetinae,
pubmed-meshheading:12237170-Genetic Engineering,
pubmed-meshheading:12237170-Homeodomain Proteins,
pubmed-meshheading:12237170-Immunohistochemistry,
pubmed-meshheading:12237170-KCNQ Potassium Channels,
pubmed-meshheading:12237170-KCNQ1 Potassium Channel,
pubmed-meshheading:12237170-Long QT Syndrome,
pubmed-meshheading:12237170-Oligonucleotides, Antisense,
pubmed-meshheading:12237170-Patch-Clamp Techniques,
pubmed-meshheading:12237170-Potassium Channels,
pubmed-meshheading:12237170-Potassium Channels, Voltage-Gated,
pubmed-meshheading:12237170-Transcription Factors,
pubmed-meshheading:12237170-Transfection,
pubmed-meshheading:12237170-Two-Hybrid System Techniques
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pubmed:year |
2002
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pubmed:articleTitle |
Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system.
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pubmed:affiliation |
Department of Pharmacology, 561A PRB, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA. sabina.kupershmidt@vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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