|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0035820,
umls-concept:C0086418,
umls-concept:C0162508,
umls-concept:C0162638,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0248813,
umls-concept:C0677535,
umls-concept:C0917996,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1801960,
umls-concept:C2911684
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2002-9-17
|
|
pubmed:abstractText |
Vascular remodeling via apoptotic mechanisms is an important factor in vascular diseases. c-Jun amino-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and initiates apoptosis mainly via phosphorylation of the c-Jun transcription factor. We performed this study to clarify the roles of the JNK/c-Jun pathway and apoptosis in the pathogenesis of cerebral aneurysms.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0148-396X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
997-1002; discussion 1002-4
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12234410-Adult,
pubmed-meshheading:12234410-Aged,
pubmed-meshheading:12234410-Apoptosis,
pubmed-meshheading:12234410-Blood Vessels,
pubmed-meshheading:12234410-Cerebrovascular Circulation,
pubmed-meshheading:12234410-DNA, Single-Stranded,
pubmed-meshheading:12234410-Female,
pubmed-meshheading:12234410-Humans,
pubmed-meshheading:12234410-Immunohistochemistry,
pubmed-meshheading:12234410-Intracranial Aneurysm,
pubmed-meshheading:12234410-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:12234410-Male,
pubmed-meshheading:12234410-Middle Aged,
pubmed-meshheading:12234410-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12234410-Phosphorylation,
pubmed-meshheading:12234410-Proto-Oncogene Proteins c-jun
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Increased expression of phosphorylated c-Jun amino-terminal kinase and phosphorylated c-Jun in human cerebral aneurysms: role of the c-Jun amino-terminal kinase/c-Jun pathway in apoptosis of vascular walls.
|
|
pubmed:affiliation |
Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Japan. ytakagi@kuhp.kyoto-u.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
