Linked Life Data

12234364

Source:http://linkedlifedata.com/resource/pubmed/id/12234364

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2002-9-17
pubmed:abstractText
Polarized T cells are mobile cells optimized for migration, receptor scanning, and signaling. When in contact with antigen-presenting cells (APCs), polarized T cells can develop a spectrum of biophysical interaction modes ranging from adhesive sticking to dynamic crawling. Both static and dynamic contacts support sustained triggering of the T-cell receptor (TCR), leading to signal induction, T blast formation, and proliferation. In dynamic interactions, T cells crawl across the surface of the APC at speeds of 2-6 micro m/min and simultaneously establish an asymmetric tight yet mobile junction plane, representing a dynamic immunological synapse. In dynamic synapses three functional compartments of the polarized T cell are in close contact with the APC surface, i.e. leading edge, cell body and uropod. Through its mobility, the asymmetric junction is topographically suited for receptor scanning and engagement at the leading edge, retrograde receptor movement along the junction, and exit from the uropod. Herein we develop a model on scanning encounters between T cells and APCs that includes the simultaneous engagement of T-cell leading edge and uropod and implicates a serial receptor triggering mode in cell-cell recognition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0105-2896
pubmed:author
pubmed:issnType
Print
pubmed:volume
186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells.
pubmed:affiliation
Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany. peter.fr@mail.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't