|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2002-9-16
|
|
pubmed:abstractText |
Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antigens on their tumour cells. In this study, the expression of HLA-DR antigen was investigated by immunohistochemistry in 357 large bowel carcinomas stratified by microsatellite instability status. Sixteen per cent of the tumours showed strong HLA-DR expression and 35% had weak DR expression. We confirmed that patients with strong positive HLA-DR staining had improved survival (P<0.001) compared to patients with no HLA-DR expression. Strong epithelial HLA-DR staining was significantly associated with high level of microsatellite instability (P<0.001). In the subgroup of tumours with characteristics typical of the chromosomal instability phenotype, i.e. in microsatellite-stable tumours, the patients positive for the HLA-DR determinants showed better survival than those without HLA-DR expression. The protective effect of HLA-DR expression on survival was confirmed by multivariate analysis, both in the whole patient group and in the microsatellite-stable/microsatellite instability-low group. This might be explained by enhanced T-cell mediated anti-tumour immune responses against tumour cells in the HLA-DR positive tumours. The finding of better patient survival in the subgroup of strong HLA-DR positive microsatellite-stable tumours may have clinical implications for these patients.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10360667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10362805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10398134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10408863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10433618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10470121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10496341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10631274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10644313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10644941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10674012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10971428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-10974135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11040179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11171826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11309634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11358903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11389088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11413533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11438476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-11729105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-1478805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-1913477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-2001553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-2446645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-2856203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-3722412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-4604796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-6354239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-7607036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-7630170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8030745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8261392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8318425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8467511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8484121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8484122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8505985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8700523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8750059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-8861899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9306957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9349235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9445110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9445183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9491320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9563488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9659163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9663422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9721846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12232760-9823339
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0007-0920
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
87
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
756-62
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:12232760-Humans,
pubmed-meshheading:12232760-Age Factors,
pubmed-meshheading:12232760-Aged,
pubmed-meshheading:12232760-Colonic Neoplasms,
pubmed-meshheading:12232760-Sex Characteristics,
pubmed-meshheading:12232760-Prognosis,
pubmed-meshheading:12232760-Disease Susceptibility,
pubmed-meshheading:12232760-Female,
pubmed-meshheading:12232760-Male,
pubmed-meshheading:12232760-Middle Aged,
pubmed-meshheading:12232760-HLA-DR Antigens,
pubmed-meshheading:12232760-Neoplasm Staging,
pubmed-meshheading:12232760-Immunohistochemistry,
pubmed-meshheading:12232760-Survival Analysis
|
