Linked Life Data

12232505

Source:http://linkedlifedata.com/resource/pubmed/id/12232505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-9-16
pubmed:abstractText
Survival to old age in natural populations is enhanced by high vitality and resilience which depends upon substantial homeostasis and energetic amd metabolic efficiency underlain by genes for stress resistance. Under this assumption increased longevity follows from primary selection for stress resistance where stress targets energy carriers. Furthermore old and young fitness should be correlated irrespective of age under the stressful selection regime of natural populations. In contrast, antagonistic pleiotropy is most likely under the less rigorous selection regime of well-nourished humans and laboratory populations surviving to old age. Similarly, hormesis for longevity, for example from a mild temperature stress or restricted food intake is most likely under benign environmental conditions. Assuming that aging in natural populations depends upon ecological circumstances, large evolutionary increases in life span are unlikely under the stress theory of aging since organisms are frequently close to their limits of survival where metabolic efficiency is at a premium. Exceptions can occur in island populations and for mutants under laboratory conditions since the risks from environmental hazards are reduced, and life span becomes extended as a consequence. In modern human populations, selection for stress resistance is less intense than in earlier times which should be permissive of the accumulation of stress-sensitive mutants under the mutation-accumulation theory of aging. However, this process is ultimately likely to restrict the evolution of life-span extensions in the future especially if abiotic conditions deteriorate, when survival would depend more directly on metabolic efficiency under stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1389-5729
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-41
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Life span: does the limit to survival depend upon metabolic efficiency under stress?
pubmed:affiliation
La Trobe University, Bundoora, Vic. 3083, Australia. pparsons@senet.com.au
pubmed:publicationType
Journal Article, Review