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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-9-16
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pubmed:abstractText |
Glioblastoma multiforme (GBM) is an aggressive cancer characterized by extensive brain invasion. Matrix metalloproteinase (MMP)-9 plays a major role in this process. GBMs can be divided into two subtypes based on distinct clinical and molecular features. Primary GBMs arise de novo and frequently overexpress the epidermal growth factor receptor (EGFR) and its ligand-independent variant, EGFR variant III (EGFRvIII); secondary GBMs progress from a lower grade glioma and commonly harbor p53 mutations. Because EGFR signaling promotes MMP-9 expression and activation in other cancer cell types, we analyzed whether MMP-9 was associated with primary GBM subtype.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2894-901
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12231534-Adult,
pubmed-meshheading:12231534-Aged,
pubmed-meshheading:12231534-Brain Neoplasms,
pubmed-meshheading:12231534-Enzyme Induction,
pubmed-meshheading:12231534-Female,
pubmed-meshheading:12231534-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12231534-Genes, erbB-1,
pubmed-meshheading:12231534-Genes, p53,
pubmed-meshheading:12231534-Glioblastoma,
pubmed-meshheading:12231534-Humans,
pubmed-meshheading:12231534-Male,
pubmed-meshheading:12231534-Matrix Metalloproteinase 2,
pubmed-meshheading:12231534-Matrix Metalloproteinase 9,
pubmed-meshheading:12231534-Middle Aged,
pubmed-meshheading:12231534-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12231534-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:12231534-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12231534-Neoplasm Proteins,
pubmed-meshheading:12231534-Prognosis,
pubmed-meshheading:12231534-Receptor, Epidermal Growth Factor,
pubmed-meshheading:12231534-Signal Transduction,
pubmed-meshheading:12231534-Survival Analysis,
pubmed-meshheading:12231534-Tumor Suppressor Protein p53
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pubmed:year |
2002
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pubmed:articleTitle |
Active matrix metalloproteinase 9 expression is associated with primary glioblastoma subtype.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California 90095-1732, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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