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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-9-16
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pubmed:abstractText |
Activation of telomerase plays a critical role in unlimited proliferation and immortalization of cells. The purpose of this study was to evaluate the significance of human telomerase reverse transcriptase catalytic subunit (hTERT) as a prognostic marker. The expression of hTERT in a large population of 153 patients with stage I non-small cell lung cancer was analyzed using the in situ hybridization technique. We found that diffuse and clear hTERT expression was present in 51 (33%) of 153 patients. Kaplan-Meier analysis showed that hTERT expression was associated with shorter overall survival (P = 0.04), shorter disease-specific survival (P = 0.03), and shorter disease-free survival (P = 0.02). Multivariate analysis confirmed this independent prognostic value of hTERT expression. Our results indicated that hTERT mRNA expression is associated with malignant tumor progression and poor outcome. hTERT may serve as a useful marker to identify patients with poor prognosis and to select patients with early-stage non-small cell lung cancer who might benefit from adjuvant treatment.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2883-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12231532-Aged,
pubmed-meshheading:12231532-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:12231532-Cause of Death,
pubmed-meshheading:12231532-DNA-Binding Proteins,
pubmed-meshheading:12231532-Disease-Free Survival,
pubmed-meshheading:12231532-Female,
pubmed-meshheading:12231532-Follow-Up Studies,
pubmed-meshheading:12231532-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12231532-Humans,
pubmed-meshheading:12231532-In Situ Hybridization,
pubmed-meshheading:12231532-Life Tables,
pubmed-meshheading:12231532-Lung Neoplasms,
pubmed-meshheading:12231532-Male,
pubmed-meshheading:12231532-Middle Aged,
pubmed-meshheading:12231532-Neoplasm Proteins,
pubmed-meshheading:12231532-Neoplasm Staging,
pubmed-meshheading:12231532-Prognosis,
pubmed-meshheading:12231532-Proportional Hazards Models,
pubmed-meshheading:12231532-RNA, Messenger,
pubmed-meshheading:12231532-RNA, Neoplasm,
pubmed-meshheading:12231532-Survival Analysis,
pubmed-meshheading:12231532-Telomerase,
pubmed-meshheading:12231532-Tumor Markers, Biological
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pubmed:year |
2002
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pubmed:articleTitle |
hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer.
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pubmed:affiliation |
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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