Linked Life Data

12231197

Source:http://linkedlifedata.com/resource/pubmed/id/12231197

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-9-16
pubmed:abstractText
The mechanisms underlying UV-induced immunosuppression and the development of UV-induced skin cancer have been intensively investigated for decades. In particular, UV-induced DNA damage and UV-induced suppression of cellular immune responses were analyzed in great detail. During this time, several cellular and genetic pathways were identified, that are involved in photoimmunology and photocarcinogenesis. However, the direct effects of the complex UV-induced pathways on immunosuppression or on cutaneous tumor generation in vivo have not been able to be characterized with certainty so far. With the increasing availability of mutant mice that lack or overexpress certain genes, more information can be obtained with respect to the functional importance of individual gene products and the signaling pathways involved in UV-mediated immunomodulation and cancer development. This article is an overview of the results of UV-induced immunosuppression and photocarcinogenesis experiments obtained in different mutant mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1046-2023
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Use of mutant mice in photoimmunological and photocarcinogenic investigations.
pubmed:affiliation
Department of Dermatology, University of Münster, Von-Esmarch-Strasse 58, D-48149 Münster, Germany. beisser@uni-muenster.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't