Source:http://linkedlifedata.com/resource/pubmed/id/12230024
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
2002-9-16
|
| pubmed:abstractText |
The purpose of this study was to determine if the adverse effects of interferon (IFN) in hepatitis C patients could be reduced by treatment with Japanese Oriental (Kampo) medicine. Twelve patients with chronic hepatitis C were treated with a combination of IFN-beta and either Mao-to or Dai-seiryu-to (groups A and B), and 16 patients were treated with IFN-beta alone (group C). Mao-to was administered to eight patients and Dai-seiryu-to was administered to four in groups A and B, respectively. Adverse effects were evaluated by clinical and laboratory examinations. The severity of symptoms was daily self-classified into four categories (1: none, 2: very slight, 3: moderate, and 4: serious), using a questionnaire consisting of 29 items. Scores of symptom such as discomfort and fever in group A, and discomfort, general malaise, paresthesia and arthralgia in group B were significantly lower than those in group C (p < 0.05). In all patients, HCV-RNA was negative at the end of the treatment, and serum alanine aminotransferase (ALT) levels had normalized transiently in all group A and B patients with genotype 1b by 2 weeks after cessation of IFN treatment. This study indicates that Kampo medicines are useful for reducing the adverse effects accompanying IFN treatment in patients with chronic hepatitis C without reducing the antiviral effects.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0192-415X
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| pubmed:author |
pubmed-author:HayashiJunJ,
pubmed-author:ImaiKazuakiK,
pubmed-author:KainumaMosaburoM,
pubmed-author:KashiwagiSeizaburoS,
pubmed-author:KohtaKazufumiK,
pubmed-author:MantaniNaokiN,
pubmed-author:MitsumaTadamichiT,
pubmed-author:SakaiShinyaS,
pubmed-author:ShimadaYutakaY,
pubmed-author:TerasawaKatsutoshiK
|
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
355-67
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:12230024-Adult,
pubmed-meshheading:12230024-Aged,
pubmed-meshheading:12230024-Alanine Transaminase,
pubmed-meshheading:12230024-Antiviral Agents,
pubmed-meshheading:12230024-Chromatography, High Pressure Liquid,
pubmed-meshheading:12230024-Drugs, Chinese Herbal,
pubmed-meshheading:12230024-Female,
pubmed-meshheading:12230024-Fever,
pubmed-meshheading:12230024-Hepatitis C, Chronic,
pubmed-meshheading:12230024-Humans,
pubmed-meshheading:12230024-Interferon-beta,
pubmed-meshheading:12230024-Male,
pubmed-meshheading:12230024-Medicine, Kampo,
pubmed-meshheading:12230024-Middle Aged,
pubmed-meshheading:12230024-Phytotherapy,
pubmed-meshheading:12230024-Plants, Medicinal,
pubmed-meshheading:12230024-Questionnaires,
pubmed-meshheading:12230024-RNA, Viral,
pubmed-meshheading:12230024-Severity of Illness Index
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
The efficacy of herbal medicine (kampo) in reducing the adverse effects of IFN-beta in chronic hepatitis C.
|
| pubmed:affiliation |
Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Japan. Kainuma@ms.toyama-mpu.ac.jp
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| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|