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| pubmed-article:12225959 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:12225959 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:12225959 | lifeskim:mentions | umls-concept:C1415619 | lld:lifeskim |
| pubmed-article:12225959 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12225959 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12225959 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12225959 | pubmed:dateCreated | 2002-9-12 | lld:pubmed |
| pubmed-article:12225959 | pubmed:abstractText | Lung ischemia-reperfusion (I-R) is an important model of oxidant-mediated acute lung and vascular injury. Heme oxygenase-1 (HO-1) is a cytoprotective gene that is markedly induced by lung I-R injury. HO-1 mRNA is increased in mouse lung after 30 min of lung hilar clamping (ischemia) followed by 2-6 h of unclamping (reperfusion) compared with control mice. In a variety of vascular cell types, HO-1 mRNA is induced after 24 h of anoxia followed by 30 min-1 h of reoxygenation (A-R). Transfection studies reveal that the promoter and 5'-distal enhancer E1 are necessary and sufficient for increased HO-1 gene transcription after A-R. Immunoblotting studies show all three subfamilies of MAPKs (ERK, JNK, and p38) are activated by 15 min of reperfusion. We also demonstrate that HO-1 gene transcription after A-R involves ERK, JNK, and p38 MAPK pathways. Together, our data show that I-R not only induces HO-1 gene expression in mouse lungs and vascular cells but that gene transcription occurs via the promoter and E1 enhancer and involves upstream MAPK pathways. | lld:pubmed |
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| pubmed-article:12225959 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12225959 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12225959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12225959 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12225959 | pubmed:issn | 1040-0605 | lld:pubmed |
| pubmed-article:12225959 | pubmed:author | pubmed-author:ChoiAugustine... | lld:pubmed |
| pubmed-article:12225959 | pubmed:author | pubmed-author:PotterRichard... | lld:pubmed |
| pubmed-article:12225959 | pubmed:author | pubmed-author:AlamJawedJ | lld:pubmed |
| pubmed-article:12225959 | pubmed:author | pubmed-author:LeePatty JPJ | lld:pubmed |
| pubmed-article:12225959 | pubmed:author | pubmed-author:ZhangXuchenX | lld:pubmed |
| pubmed-article:12225959 | pubmed:author | pubmed-author:ZhongRobertR | lld:pubmed |
| pubmed-article:12225959 | pubmed:author | pubmed-author:BedardEric... | lld:pubmed |
| pubmed-article:12225959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12225959 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:12225959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12225959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12225959 | pubmed:pagination | L815-29 | lld:pubmed |
| pubmed-article:12225959 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12225959 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12225959 | pubmed:articleTitle | Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. | lld:pubmed |
| pubmed-article:12225959 | pubmed:affiliation | Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. | lld:pubmed |
| pubmed-article:12225959 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12225959 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12225959 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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