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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-9-12
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pubmed:abstractText |
Stiff-man syndrome (SMS) is a rare autoimmune disorder of the central nervous system associated with autoantibodies to glutamate decarboxylase (GAD). We isolated five brain-reactive human monoclonal antibodies, with reactivity distinct from GAD, from peripheral blood of a patient newly diagnosed with SMS. Two antibodies reacted with both Purkinje cells and ependymal cells, and precipitated an 80-kDa protein from rat neuronal primary cultures, which was also recognized by 12% (3/25) of SMS sera and 13% (2/15) of SMS cerebrospinal fluid (CSF) samples. The corresponding antigen was identified as 17 beta-hydroxysteroid dehydrogenase type 4 and may represent a possible novel target of autoimmunity in SMS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/17-Hydroxysteroid Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Enoyl-CoA Hydratase,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/HSD17B4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hsd17b4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Hsd17b4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Hydro-Lyases,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-93
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12225901-17-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:12225901-Amino Acid Sequence,
pubmed-meshheading:12225901-Animals,
pubmed-meshheading:12225901-Antibodies, Monoclonal,
pubmed-meshheading:12225901-Autoantibodies,
pubmed-meshheading:12225901-Cells, Cultured,
pubmed-meshheading:12225901-Central Nervous System,
pubmed-meshheading:12225901-Enoyl-CoA Hydratase,
pubmed-meshheading:12225901-Estradiol,
pubmed-meshheading:12225901-Female,
pubmed-meshheading:12225901-Fetus,
pubmed-meshheading:12225901-Humans,
pubmed-meshheading:12225901-Hydro-Lyases,
pubmed-meshheading:12225901-Mice,
pubmed-meshheading:12225901-Middle Aged,
pubmed-meshheading:12225901-Molecular Sequence Data,
pubmed-meshheading:12225901-Multienzyme Complexes,
pubmed-meshheading:12225901-Neurons,
pubmed-meshheading:12225901-Purkinje Cells,
pubmed-meshheading:12225901-Rats,
pubmed-meshheading:12225901-Rats, Wistar,
pubmed-meshheading:12225901-Recombinant Fusion Proteins,
pubmed-meshheading:12225901-Stiff-Person Syndrome
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pubmed:year |
2002
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pubmed:articleTitle |
Stiff-man syndrome: identification of 17 beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen.
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pubmed:affiliation |
Department of Orthopedic Surgery, University of Heidelberg, Schlierbacher Landstr. 200, 69118, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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