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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-9-12
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pubmed:abstractText |
The phenotype and antigen-specificity of T cells expanded by mitogenic stimulation from intra-ocular fluid (IOF) samples of affected eyes of six Behçet's disease (BD) patients, and seven patients with other uveitis entities, were determined. High numbers of gammadelta T cells, predominantly Vgamma9Vdelta2 T cells, were only detected in the IOF-derived TCL of three BD patients. Whereas no TCL responded to heat shock protein (HSP) 65 kDa, reactivity to isopentyl pyrophosphate (IPP) and related non-peptide prenyl pyrophosphates (PPP) was restricted to the gammadelta T cell containing TCL. Upon IPP stimulation, these TCL secreted IFN-gamma but no IL-4. By single-cell analysis of intracellular IFN-gamma production and CD69 expression the IOF-derived IPP-specific T cells were identified as CD4(-)CD8(-) gammadelta T cells. The data presented suggest the infiltration of PPP-specific Vgamma9Vdelta2 Th1-like cells into the eye of BD patients with uveitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Diphosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
46-54
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12225887-Adult,
pubmed-meshheading:12225887-Aged,
pubmed-meshheading:12225887-Antigen Presentation,
pubmed-meshheading:12225887-Antigens, CD,
pubmed-meshheading:12225887-Antigens, CD3,
pubmed-meshheading:12225887-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:12225887-Aqueous Humor,
pubmed-meshheading:12225887-Behcet Syndrome,
pubmed-meshheading:12225887-CD4-CD8 Ratio,
pubmed-meshheading:12225887-Chemotaxis, Leukocyte,
pubmed-meshheading:12225887-Child,
pubmed-meshheading:12225887-Cytokines,
pubmed-meshheading:12225887-Diphosphates,
pubmed-meshheading:12225887-Epitopes,
pubmed-meshheading:12225887-Eye,
pubmed-meshheading:12225887-Female,
pubmed-meshheading:12225887-Flow Cytometry,
pubmed-meshheading:12225887-Humans,
pubmed-meshheading:12225887-Interferon-gamma,
pubmed-meshheading:12225887-Lectins, C-Type,
pubmed-meshheading:12225887-Male,
pubmed-meshheading:12225887-Middle Aged,
pubmed-meshheading:12225887-Protein Prenylation,
pubmed-meshheading:12225887-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:12225887-T-Lymphocytes
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pubmed:year |
2002
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pubmed:articleTitle |
Vgamma9Vdelta2 T cells recovered from eyes of patients with Behçet's disease recognize non-peptide prenyl pyrophosphate antigens.
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pubmed:affiliation |
Rotterdam Eye Hospital, PO Box 70030, 3000 LM, Rotterdam, The Netherlands. Verjans@viro.fgg.eur.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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