Source:http://linkedlifedata.com/resource/pubmed/id/12225886
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2002-9-12
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| pubmed:abstractText |
The contribution of peripheral macrophage was assessed in cuprizone intoxication, a model of demyelination and remyelination in which the blood-brain barrier remains intact. Flow cytometry of brain cells isolated from cuprizone-treated mice revealed an increase in the percentage of Mac-1(+)/CD45(hi) peripheral macrophage. To confirm these results in situ, C57BL/6 mice were lethally irradiated, transplanted with bone marrow from GFP-transgenic mice, and exposed to cuprizone. GFP(+) peripheral macrophages were seen in the CNS after 2 weeks of treatment, and infiltration continued through 6 weeks. While the peripheral macrophages were far outnumbered by the resident microglia, their recruitment across the blood-brain barrier alludes to a potentially important role.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0165-5728
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
130
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
32-45
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12225886-Animals,
pubmed-meshheading:12225886-Antigens, CD3,
pubmed-meshheading:12225886-Antigens, CD45,
pubmed-meshheading:12225886-Blood-Brain Barrier,
pubmed-meshheading:12225886-Bone Marrow Cells,
pubmed-meshheading:12225886-Bone Marrow Transplantation,
pubmed-meshheading:12225886-Central Nervous System,
pubmed-meshheading:12225886-Chemotaxis, Leukocyte,
pubmed-meshheading:12225886-Demyelinating Autoimmune Diseases, CNS,
pubmed-meshheading:12225886-Disease Models, Animal,
pubmed-meshheading:12225886-Flow Cytometry,
pubmed-meshheading:12225886-Macrophage-1 Antigen,
pubmed-meshheading:12225886-Macrophages,
pubmed-meshheading:12225886-Male,
pubmed-meshheading:12225886-Mice,
pubmed-meshheading:12225886-Mice, Inbred C57BL,
pubmed-meshheading:12225886-Mice, Transgenic,
pubmed-meshheading:12225886-Radiation Chimera
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| pubmed:year |
2002
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| pubmed:articleTitle |
Peripheral macrophage recruitment in cuprizone-induced CNS demyelination despite an intact blood-brain barrier.
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| pubmed:affiliation |
Department of Microbiology and Immunology, University of North Carolina, 27599, Chapel Hill, NC, USA
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|